The life process of eukaryotic cells depends on functionally specialized organelles within the cell. Organelles communicate with each other to mediate the transfer of proteins, lipids, ions, and metabolites. Disorders in this process are closely linked to a variety of severe diseases such as neurodegenerative diseases, cancer, diabetes and other rare diseases. However, little is known about the molecular basis of organelle communication in health and disease. We are interested in how one organelle communicates with another. In particular, we are interested in the finely tuned transfer of specific lipids between organelles and try to understand how this transfer takes place and what functions it has in the context of organelle, cell and tissue.
Research
Publications
2024
Yuanjiao Du(#), Xinyu Fan(#), Chunyu Song, Weiping Chang, Juan Xiong, Lin Deng, and Wei-Ke Ji* (2024) Sec23IP recruits the Cohen syndrome factor VPS13B/COH1 to ER exit site-Golgi interface for tubular ERGIC formation. Journal of Cell Biology. 2024 Dec 2;223(12):e202402083. doi: 10.1083/jcb.202402083. Epub 2024 Oct 1. PMID: 39352497; PMCID: PMC11457499.
Jingru Wang (#), Juan Xiong (#), Shuhan Zhang, Dongchen Li, Qingzhu Chu, Weiping Chang, Lin Deng* and Wei-Ke Ji*(2024) Biogenesis of Rab14 positive endosome buds at Golgi-endosome contacts by the RhoBTB3-SHIP164-Vps26B complex. Cell Discovery, 10:38, 10.1038/s41421-024-00651-6.
Xuewen Hu#, Yirui Cai# and Wei-Ke Ji* (2024) Recent advances on Synaptotagmin-like mitochondrial-lipid binding protein domain containing lipid transfer proteins. Contact. 7:1-7.
Qingzhu Chu# and Wei-Ke Ji* (2024) Lipid transfer at mitochondrial membrane contact sites. Mitochondrial Communications. 2:123-128.
2023
Yuanjiao Du(#), Weiping Chang, Lei Gao, Lin Deng, and Wei-Ke Ji* (2023) Tex2 is required for lysosomal functions at TMEM55-dependent ER contacts. Journal of Cell Biology. 222(4): e202205133.
Du Y, Hu X, Chang W, Deng L, Wei-ke Ji*, Xiong J* (2023) A Possible Role of VPS13B in the Formation of Golgi-Lipid Droplet Contacts Associating with the ER. Contact (Thousand Oaks). 6:25152564231195718. doi: 10.1177/25152564231195718. PMID: 38090145; PMCID: PMC10714374.
Chu, Q.#, Wang, J.#, Du, Y., Zhou, T., Shi, A., Xiong, J.*, Wei-ke Ji*, and Deng, L.* (2023) Oligomeric CHMP7 mediates three-way ER junctions and ER-mitochondria interactions. Cell Death & Differentiation; doi:10.1038/s41418-022-01048-2 PMID:35962186.
2022
Yuan Gao(#), Juan Xiong, Qingzhu Chu, Wei-ke Ji* (2022) PDZD8 mediated lipid transfer at ER-LE/lys contacts is required for LE/lys positioning and neurite outgrowth. Journal of Cell Science, JOCES/2020/255026.
2021
Jingru Wang(#), Na Fang(#), Juan Xiong(#), Yuanjiao Du, Yue Cao, Wei-ke Ji* (2021) An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions. Nature Communications, 10.1038/s41467-021-21525-5.
Du Y, Wang J, Xiong J, Fang N, Wei-ke Ji* (2021) VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Mol Biol Cell. 32(16):1474-1486. doi: 10.1091/mbc.E21-03-0097. Epub 2021 Jun 16. PMID: 34133214; PMCID: PMC8351740.
People
Lab members at Tongji campus in the winter of 2023.
Contact
Postdoc positions available！
We are always looking for talented and motivated individuals to join our team! Contact weike_ji1985@163.com if interested!